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Publications from the past 5 years.
A complete publication list can be found on Google Scholar


Structural biases in disordered proteins are prevalent in the cell. D Moses, K Guadalupe, F Yu, E Flores, A Perez, R McAnelly, N M Shamoon, E Cuevas-Zepeda, A Merg, E W. Martin, A S. Holehouse, S Sukenik.

Article (Nat. Struct. Mol. Bio.)

Disordered proteins interact with the chemical environment to tune their protective function during drying. Shraddha KC, Kenny Nguyen, Vincent Nicholson, Annie Walgren, Edith Gollub, Sofia Romero, Alex S. Holehouse, Shahar Sukenik, Thomas C. Boothby 


Labile assembly of a tardigrade protein induces biostasis. S Sanchez-Martinez... F Yu, E Gollub... S Sukenik... TC Boothby 

Article (Protein Science)

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Intrinsically disordered regions are poised to act as sensors of cellular chemistry. David Moses, Garrett M. Ginell, Alex S. Holehouse, Shahar Sukenik

Review (Trends Biochem. Sci)

Helicity of a tardigrade disordered protein promotes desiccation tolerance. Sourav Biswas, Edith Gollub, Feng Yu, Garrett Ginell, Shahar Sukenik, Thomas C. Boothby

Article (Protein Science)

When Phased Without Water: Biophysics of Cellular Desiccation, from Biomolecules to Condensates. Paulette Sofia Romero-Perez, Yanniv Dorone, Eduardo Flores, Shahar Sukenik, Steven Boeynaems

Review (Chem. Rev.)

Structural preferences shape the entropic force of disordered protein ensembles. Feng Yu, Shahar Sukenik

Article (J. Phys. Chem. B)

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YAP condensates are highly organized hubs for YAP/TEAD transcription. Siyuan Hao, Hannah Fuehrer, Eduardo Flores, Justin Demmerle, Jennifer Lippincott-Schwartz, Zhe Liu, Shahar Sukenik, Danfeng Kai


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Hidden structure in disordered proteins is adaptive to intracellular changes. D Moses, K Guadalupe, F Yu, E Flores, A Perez, R McAnelly, N M Shamoon, E Cuevas-Zepeda, A Merg, E W. Martin, A S. Holehouse, S Sukenik

Article (Preprint)

Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells. Cuevas-Velazquez, C.L., Vellosillo, T., Guadalupe, K. et al.

Article (Nat Commun)

Computational modelling of protein conformational changes-application to the opening SARS-CoV-2 spike. A Kucherova, S Strango, S Sukenik, M Theillard

Article (Journal of Computational Physics)

A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation, Y Dorone, S Boeynaems,

E Flores,...S Sukenik, A D Gitler, S Y Rhee

Article (Cell)


Probing the Hidden Sensitivity of Intrinsically Disordered Proteins to their Chemical Environment

D Moses, F Yu, G Ginell, N M Shamoon, P S Koenig, A S Holehouse, S Sukenik

Article (J. Phys. Chem. Lett.) 

Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells

C L Cuevas-Velazquez, ..., S Sukenik, J R Dinneny


Controlling Structural Bias in Intrinsically Disordered Proteins Using Solution Space Scanning. A S Holehouse, S Sukenik

Article (J. Chem. Theor. Comput.) 



In-cell titration of small solutes controls protein stability and aggregation

S Sukenik, M Salam, Y Wang, M Gruebele

JACS, 140, 33, 10497-10503

How does solvation in the cell affect protein folding and binding? 

CM Davis, M Gruebele, S Sukenik

Current opinion in structural biology 48, 23-29

Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression

D Cai, D Feliciano, P Dong, E Flores, M Gruebele, N Porat-Shilom, S Sukenik, Z Liu, J Lippincott-Schwartz

Nature Cell Biology, 21, 578–1589



Weak protein–protein interactions in live cells are quantified by cell-volume modulation

S Sukenik, P Ren, M Gruebele

PNAS 114 (26), 6776-6781

TMAO mediates effective attraction between lipid membranes by partitioning unevenly between bulk and lipid domains

S Sukenik, S Dunsky, A Barnoy, I Shumilin, D Harries

Physical Chemistry Chemical Physics 19 (44), 29862-29871


Globular protein folding in vitro and in vivo

M Gruebele, K Dave, S Sukenik

Annual review of biophysics 45, 233-251


Can Local Probes Go Global? A Joint Experiment–Simulation Analysis of λ6–85 Folding

S Sukenik, TV Pogorelov, M Gruebele

The Journal of Physical Chemistry Letters 7 (11), 1960-1965


The Ec-NhaA antiporter switches from antagonistic to synergistic antiport upon a single point mutation

M Dwivedi, S Sukenik, A Friedler, E Padan

Scientific reports 6, 23339


Competing processes of micellization and fibrillization in native and reduced casein proteins

I Portnaya, S Avni, E Kesselman, Y Boyarski, S Sukenik, D Harries, N Dan, U. Cogan, D. Danino

Physical Chemistry Chemical Physics 18 (32), 22516-22525

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