PAPERS
Publications from the past 5 years.
A complete publication list can be found on Google Scholar
2024
Helicity of a tardigrade disordered protein contributes to its protective function during desiccation. Biswas S, Gollub E, Yu F, Ginell G, Holehouse A, Sukenik S, et al. Protein Science. 2024; 33(2):e4872. Article
Structural biases in disordered proteins are prevalent in the cell. D Moses, K Guadalupe, F Yu, E Flores, A Perez, R McAnelly, N M Shamoon, E Cuevas-Zepeda, A Merg, E W. Martin, A S. Holehouse, S Sukenik. Nat Struct Mol Biol 31, 283–292 (2024).
Disordered proteins interact with the chemical environment to tune their protective function during drying. Shraddha KC, Kenny Nguyen, Vincent Nicholson, Annie Walgren, Edith Gollub, Sofia Romero, Alex S. Holehouse, Shahar Sukenik, Thomas C. Boothby
Labile assembly of a tardigrade protein induces biostasis. S Sanchez-Martinez... F Yu, E Gollub... S Sukenik... TC Boothby
Article (Protein Science)
2023
Intrinsically disordered regions are poised to act as sensors of cellular chemistry. David Moses, Garrett M. Ginell, Alex S. Holehouse, Shahar Sukenik
Review (Trends Biochem. Sci)
Helicity of a tardigrade disordered protein promotes desiccation tolerance. Sourav Biswas, Edith Gollub, Feng Yu, Garrett Ginell, Shahar Sukenik, Thomas C. Boothby
When Phased Without Water: Biophysics of Cellular Desiccation, from Biomolecules to Condensates. Paulette Sofia Romero-Perez, Yanniv Dorone, Eduardo Flores, Shahar Sukenik, Steven Boeynaems
Structural preferences shape the entropic force of disordered protein ensembles. Feng Yu, Shahar Sukenik
2022
YAP condensates are highly organized hubs for YAP/TEAD transcription. Siyuan Hao, Hannah Fuehrer, Eduardo Flores, Justin Demmerle, Jennifer Lippincott-Schwartz, Zhe Liu, Shahar Sukenik, Danfeng Kai
2021
Hidden structure in disordered proteins is adaptive to intracellular changes. D Moses, K Guadalupe, F Yu, E Flores, A Perez, R McAnelly, N M Shamoon, E Cuevas-Zepeda, A Merg, E W. Martin, A S. Holehouse, S Sukenik
Article (Preprint)
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells. Cuevas-Velazquez, C.L., Vellosillo, T., Guadalupe, K. et al.
Article (Nat Commun)
Article (Molecular Biology of the Cell)
Computational modelling of protein conformational changes-application to the opening SARS-CoV-2 spike. A Kucherova, S Strango, S Sukenik, M Theillard
Article (Journal of Computational Physics)
A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation, Y Dorone, S Boeynaems,
E Flores,...S Sukenik, A D Gitler, S Y Rhee
Article (Cell)
2020
Probing the Hidden Sensitivity of Intrinsically Disordered Proteins to their Chemical Environment
D Moses, F Yu, G Ginell, N M Shamoon, P S Koenig, A S Holehouse, S Sukenik
Article (J. Phys. Chem. Lett.)
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells
C L Cuevas-Velazquez, ..., S Sukenik, J R Dinneny
Controlling Structural Bias in Intrinsically Disordered Proteins Using Solution Space Scanning. A S Holehouse, S Sukenik
Article (J. Chem. Theor. Comput.)
2019
2018
In-cell titration of small solutes controls protein stability and aggregation
S Sukenik, M Salam, Y Wang, M Gruebele
How does solvation in the cell affect protein folding and binding?
CM Davis, M Gruebele, S Sukenik
Current opinion in structural biology 48, 23-29
Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression
D Cai, D Feliciano, P Dong, E Flores, M Gruebele, N Porat-Shilom, S Sukenik, Z Liu, J Lippincott-Schwartz
2017
Weak protein–protein interactions in live cells are quantified by cell-volume modulation
S Sukenik, P Ren, M Gruebele
PNAS 114 (26), 6776-6781
TMAO mediates effective attraction between lipid membranes by partitioning unevenly between bulk and lipid domains
S Sukenik, S Dunsky, A Barnoy, I Shumilin, D Harries
Physical Chemistry Chemical Physics 19 (44), 29862-29871
2016
Globular protein folding in vitro and in vivo
M Gruebele, K Dave, S Sukenik
Annual review of biophysics 45, 233-251
Can Local Probes Go Global? A Joint Experiment–Simulation Analysis of λ6–85 Folding
S Sukenik, TV Pogorelov, M Gruebele
The Journal of Physical Chemistry Letters 7 (11), 1960-1965
The Ec-NhaA antiporter switches from antagonistic to synergistic antiport upon a single point mutation
M Dwivedi, S Sukenik, A Friedler, E Padan
Scientific reports 6, 23339
Competing processes of micellization and fibrillization in native and reduced casein proteins
I Portnaya, S Avni, E Kesselman, Y Boyarski, S Sukenik, D Harries, N Dan, U. Cogan, D. Danino
Physical Chemistry Chemical Physics 18 (32), 22516-22525
